Imitrex

Imitrex is used to stop migraine headaches after they start. It works by narrowing blood vessels around the brain. Imitrex may cause you to feel tired or sleepy.

Imitrex Overview

Reviewed: June 25, 2012
Updated: 

Imitrex is a prescription medication used to treat migraine headaches once they have started. Imitrex belongs to a group of drugs called serotonin receptor agonists or "triptans", which relieve pain by narrowing blood vessels around the brain.

This medication comes in tablet and nasal spray and is taken at the first sign of a migraine headache.

Imitrex is also available as an injectable form to be injected under the skin. Imitrex injection is also used to treat cluster headaches in adults.

Common side effects of Imitrex include tingling or numbness in fingers or toes, weakness, tiredness. Imitrex can cause drowsiness. Do not drive a car or operate machinery if you have these symptoms.

How was your experience with Imitrex?

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What are you taking Imitrex for?

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  • Other
  • Cluster Headache

How long have you been taking it?

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  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Imitrex work for you?

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Imitrex Cautionary Labels

precautionsprecautionsprecautionsprecautions

Uses of Imitrex

Sumatriptan is a prescription medication used to treat migraine headaches once they have started, with or without aura.

Sumatriptan injection is also used to treat cluster headaches in adults.

This medication may be prescribed for other uses.

Manufacturer

Imitrex Drug Class

Imitrex is part of the drug class:

Side Effects of Imitrex

Sumatriptan may cause serious side effects. See “Drug Precautions”.

These serious side effects include:

  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:
    • sudden or severe stomach pain
    • stomach pain after meals
    • weight loss
    • nausea or vomiting
    • constipation or diarrhea
    • bloody diarrhea
    • fever
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • feeling of heaviness or tightness in your leg muscles
    • burning or aching pain in your feet or toes while resting
    • numbness, tingling, or weakness in your legs
    • cold feeling or color changes in 1 or both legs or feet
  • hives (itchy bumps); swelling of your tongue, mouth, or throat
  • medication overuse headaches. Some people who take/use too much sumatriptan may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with sumatriptan.

The most common side effects of sumatriptan tablets include:

  • tingling or numbness in your fingers or toes
  • dizziness
  • warm, hot, burning feeling to your face (flushing)
  • feeling weak, drowsy, or tired

The most common side effects of sumatriptan nasal spray include:

  • dizziness
  • warm, hot, burning feeling to your face (flushing)
  • discomfort of your neck, throat, or nose
  • unusual or bad taste in your mouth
  • feeling weak, drowsy, or tired
  • sensitivity to loud noises

The most common side effects of sumatriptan injection include:

  • injection site reactions such as redness, pain, or swelling
  • tingling or numbness in your fingers or toes
  • dizziness
  • warm, hot, burning feeling to your face (flushing)
  • discomfort or stiffness in your neck
  • feeling weak, drowsy, or tired

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of sumatriptan. For more information, ask your healthcare provider or pharmacist.

Imitrex Interactions

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Sumatriptan and other medicines may affect each other, causing side effects.

Especially tell your healthcare provider if you take:

  • selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil), fluoxetine (Prozac, Sarafem), and fluvoxamine (Luvox)
  • serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) venlafaxine (Effexor)
  • monoamine oxidase inhibitors (MAOIs) such as tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), and rasagiline (Azilect)
  • other ergot-containing medications such as dihydroergotamine (D.H.E. 45, MIGRANAL) or methysergide
  • other triptans such as sumatriptan (Imitrex, Treximet), eletriptan (Relpax), almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), and zolmitriptan (Zomig)

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Imitrex Precautions

Sumatriptan can cause serious side effects, including:

Heart attack and other heart problems. Heart problems may lead to death. Stop taking sumatriptan and get emergency medical help right away if you have any of the following symptoms of a heart attack:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • chest pain or chest discomfort that feels like heavy pressure, squeezing, or fullness
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded

Sumatriptan is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease
  • are a female who has gone through menopause
  • are a male over age 40

Serotonin syndrome. Serotonin syndrome is a serious and life-threatening problem that can happen in people taking sumatriptan, especially if sumatriptan is used with anti-depressant medicines called selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:

  • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
  • fast heartbeat
  • changes in blood pressure
  • high body temperature
  • tight muscles
  • trouble walking
  • nausea, vomiting, or diarrhea

Medication overuse headaches. Some people who take/use too much sumatriptan may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with sumatriptan.

Seizures. Seizures have happened in people taking sumatriptan who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take sumatriptan.

Do not take sumatriptan if you have:

  • heart problems or a history of heart problems
  • narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)
  • uncontrolled high blood pressure
  • severe liver problems
  • hemiplegic migraines or basilar migraines. If you are not sure if you have these types of migraines, ask your healthcare provider.
  • had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • taken any of the following medicines in the last 24 hours:
    • almotriptan (Axert)
    • eletriptan (Relpax)
    • frovatriptan (Frova)
    • naratriptan (Amerge)
    • rizatriptan (Maxalt, Maxalt-MLT)
    • sumatriptan and naproxen (Treximet)
    • ergotamines (Cafergot, Ergomar, Migergot)
    • dihydroergotamine (D.H.E. 45, Migranal)
  • an allergy to sumatriptan or any of the ingredients in sumatriptan. 

Sumatriptan can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

Imitrex Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of sumatriptan there are no specific foods that you must exclude from your diet when receiving sumatriptan.

Inform MD

Before you take sumatriptan, tell your healthcare provider about all of your medical conditions, including if you:

  • have high blood pressure
  • have high cholesterol
  • have diabetes
  • smoke
  • are overweight
  • are a female who has gone through menopause
  • have heart disease or a family history of heart disease or stroke
  • have liver problems
  • have had epilepsy or seizures
  • are not using effective birth control
  • are pregnant or plan to become pregnant
  • become pregnant while taking sumatriptan
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Imitrex and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Sumatriptan falls into category C.  In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Imitrex and Lactation

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Sumatriptan may pass into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take sumatriptan.

Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hours after treatment with sumatriptan tablets and nasal spray.

Imitrex Usage

  • Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
  • Certain people should take their first dose of sumatriptan in their healthcare provider’s office or in another medical setting. Ask your healthcare provider if you should take your first dose in a medical setting.
  • Take sumatriptan exactly as your healthcare provider tells you to take it.Do not take more or less of it or take it more often than prescribed by your doctor.
  • Your healthcare provider may change your dose. Do not change your dose without first talking to your healthcare provider.

Sumatriptan tablets:

  • Take sumatriptan tablets with water or other liquids.
  • If you do not get any relief after your first sumatriptan tablet, do not take a second tablet without first talking with your healthcare provider.
  • If your headache comes back or you only get some relief from your headache, you can take a second tablet 2 hours after the first tablet.
  • Do not take more than a total of 200 mg of sumatriptan tablets in a 24‑hour period.
  • Some people who take too many sumatriptan tablets may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with sumatriptan.

Sumatriptan nasal spray:

Before using sumatriptan nasal spray, read the "Instructions for Use" at the end of the Patient Information leaflet that comes with the medicine.

  • Certain people should take their first dose of sumatriptan nasal spray in their healthcare provider’s office or in another medical setting. Ask your healthcare provider if you should take your first dose in a medical setting.
  • Use sumatriptan nasal spray exactly as your healthcare provider tells you to use it.
  • Your healthcare provider may change your dose. Do not change your dose without first talking with your healthcare provider.
  • If you do not get any relief after your first nasal spray, do not use a second nasal spray without first talking with your healthcare provider.
  • If your headache comes back after the first nasal spray or you only get some relief from your headache, you can use a second nasal spray 2 hours after the first nasal spray.
  • Do not take more than a total of 40 mg of sumatriptan nasal spray in a 24‑hour period.
  • It is not known how using sumatriptan nasal spray for a long time affects the nose and throat.
  • Some people who use too much sumatriptan Nasal Spray may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with sumatriptan nasal spray.

Sumatriptan injection:

Imitrex Injection comes in an autoinjection device so that you can self-inject this medication into your thigh or deltoid area (shoulder joint). Your doctor or pharmacist should show you how to load the injector and administer the medication.

For adults, the usual dose is a single injection given just below the skin. You should give an injection as soon as the symptoms of your migraine start, but it may be given at any time during an attack. You may give a second injection if your migraine symptoms come back.

If your symptoms do not get better after the first injection, do not give a second injection for the same attack without first talking with your healthcare provider. Do not give more than two 6-mg doses in any 24-hour period. Allow at least 1 hour between each dose.

If you take too much sumatriptan, call your healthcare provider or go to the nearest hospital emergency room right away.

You should write down when you have headaches and when you take sumatriptan so you can talk with your healthcare provider about how sumatriptan is working for you.

Imitrex Dosage

Take sumatriptan exactly as prescribed. Follow the directions on your prescription label carefully.

  • The maximum recommended daily dose of sumatriptan tablets is 200 mg.
  • The maximum recommended daily dose of sumatriptan nasal spray is 40 mg.
  • The maximum recommended adult dose of sumatriptan injection is 6 mg injected subcutaneously (under the skin). The maximum recommended dose that may be given in 24 hours is two 6 mg injections separated by at least one hour.

Imitrex Overdose

If you have taken more sumatriptan than has been prescribed for you, contact either your doctor, hospital emergency department, or your local Poison Control Center.

Other Requirements

Sumatriptan injection:

  • Store sumatriptan between 36°F to 86°F (2°C to 30°C).
  • Store your medicine away from light.
  • Keep your medicine in the packaging or carrying case provided with it.

Sumatriptan tablets:

  • Store sumatriptan tablets between 36°F to 86°F (2°C to 30°C).

Sumatriptan nasal spray:

  • Store sumatriptan between 36°F to 86°F (2°C to 30°C).
  • Store your medicine away from light.

Keep this and all medicines out of the reach of children.