Libtayo is a monoclonal antibody used to treat patients with metastatic cutaneous squamous cell carcinoma. Mix drug and diluent solution by gentle inversion. Do not shake.
Libtayo is a prescription medication used to treat metastatic cutaneous squamous cell carcinoma (CSCC). Libtayo belongs to a group of drugs called monoclonal antibodies. Libtayo work by binding to its target receptor, human programmed death receptor-1 (PD-1), on T-cells. The binding results in blocking PD-1 from interacting with its ligands, PD-L1 and PD-L2, allowing the T-cells to remain active. This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional. Common side effects of Libtayo include fatigue, rash, and diarrhea.
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Uses of Libtayo
Libtayo is a prescription medication used to treat metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC in patients who cannot get curative surgery or curative radiation. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Libtayo Drug Class
Libtayo is part of the drug class:
Side Effects of Libtayo
Serious side effects have been reported with Libtayo. See the “Libtayo Precautions” section. Common side effects of Libtayo include the following:
- Musculoskeletal pain
- Decreased appetite
This is not a complete list of Libtayo side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effects that bother you or that do not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
No drug interactions have been evaluated by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.
Serious side effects have been reported with Libtayo including the following:
- Encephalopathy. Tell your healthcare provider right away if you have some or all of the following symptoms of encephalopathy:
- Loss of memory or decreased thinking ability
- Changes in personality
- Muscle twitching or rapid, uncontrollable eye movement
- Muscle loss
- Unable to swallow or speak
- Pneumonitis. Report any signs of lung problems (cough, shortness of breath, or chest pain), which may be signs of pneumonitis.
- Hepatitis. Tell your healthcare provider right away if you have some or all of the following symptoms of hepatitis:
- Yellowing of your skin or the whites of your eyes
- Severe nausea or vomiting
- Pain on the right side of your stomach
- Dark urine
- Signs of easy bleeding or bruising
- Loss of appetite
- Colitis. Report any signs of diarrhea, severe abdominal pain, or black, tarry stool. These may be signs of colitis.
- Hormone gland problems. Signs and symptoms that your hormone glands are not working properly may include:
- Rapid heart beat
- Increased sweating
- Weight gain or loss
- Increased hunger/thirst
- Increased urination
- Cold insensitivity
- Low blood pressure
- Mood or behavior changes
- Nephritis/Kidney Failure: Report any signs of kidney problems like decreased urination, dark or bloody urine, and ankle swelling.
- Skin problems: Tell your healthcare provider if you develop rashes, itching, blistering, or sores/ulcers
- Rejection of a transplanted organ. Your doctor should tell you what signs and symptoms you should monitor and report.
- Infusion (IV) reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:
- Shortness of breath or wheezing
- Back or neck pain
- Flushing/facial swelling
Libtayo Food Interactions
No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.
Before taking Libtayo, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- Are allergic to Libtayo or to any of its ingredients
- Have kidney problems
- Have liver problems
- Have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
- Have had an organ transplant
- Have lung or breathing problems
- Have diabetes
- Are pregnant or plan to become pregnant
- Are breastfeeding or plan to breastfeed
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Libtayo and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
Libtayo can cause fetal harm when administered to pregnant women. Libtayo has not been studied in pregnant women. Animal studies have shown that the mechanism by which this medication works can cause immune-mediated fatal rejection causing fetal death.
Libtayo and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
No information is available on the secretion of Libtayo in breast milk and its effects on infants who are breastfed. Due to the possibility of serious adverse reactions if introduced to infants, women should not breastfeed while on Libtayo therapy and at least 4 months after stopping therapy.
Libtayo is available in an injectable form to be given directly into a vein (IV) by a healthcare professional
The recommended dosage of Libtayo is 350 mg infused intravenously over 30 minutes every 3 weeks. Follow your doctor's instructions about your individual dosing schedule. It is important to keep all of your appointments to receive your Libtayo dose.
If you experience unacceptable toxicity or side effects become intolerable, you may need to wait longer between dose or permanently stop the medicine.