Lonsurf

treats patients with colorectal cancer who are no longer responding to other therapies.

Lonsurf Overview

Reviewed: September 22, 2015
Updated: 

Lonsurf is a prescription medication used to treat advanced colorectal cancer. It is a single product containing trifluridine and tipiracil. 

Trifluridine belongs to a group of drugs called nucleoside metabolic inhibitor. Tipiracil belongs to a group of drugs called thymidine phosphorylase inhibitor. Together these work to stop the growth and spread of cancer cells.

It is available in tablet form and is typically taken twice a day, within 1 hour of morning and evening meals.  

Common side effects of Lonsurf may include decrease in blood cell counts, fatigue, and nausea. 

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Lonsurf Cautionary Labels

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Uses of Lonsurf

Lonsurf is a prescription medication used to treat patients with an advanced form of colorectal cancer who are no longer responding to other therapies. These therapies include fluoropyrimidine, oxaliplatin and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Lonsurf Drug Class

Lonsurf is part of the drug class:

Side Effects of Lonsurf

Serious side effects have been reported with Lonsurf. See the “Lonsurf Precautions” section.

Common side effects of Lonsurf include the following:

  • anemia (low red blood cell counts)
  • neutropenia (low neutrophils)
  • fatigue
  • nausea
  • thrombocytopenia (low platelets)
  • decreased appetite
  • diarrhea
  • vomiting
  • abdominal pain
  • fever

This is not a complete list of Lonsurf side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Lonsurf Interactions

No drug interactions have been conducted by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Lonsurf Precautions

Serious side effects have been reported with Lonsurf including the following:

  • Bone marrow Suppression (Severe Myelosuppression): Contact your doctor right away if you notice signs or symptoms of infection. Your doctor will monitor your blood counts prior to and on Day 15 of each cycle. Keep all appointments for blood tests. If needed, your doctor may reduce dose and/or hold Lonsurf. 
  • Gastrointestinal toxicity:  Contact your doctor right away if you experience severe or persistent nausea, vomiting, diarrhea, or abdominal pain.
  • Low blood counts. Patients 65 years and older are at a higher risk of having low blood counts after taking Lonsurf. 
  • Embryo-Fetal Toxicity: Lonsurf can cause fetal harm when administered to a pregnant woman. Females of reproductive potential are recommended to use effective contraception during treatment with Lonsurf. 

Lonsurf is available in two strengths and you may receive both strength tablets to provide the prescribed dose. Make sure to read your prescription labels carefully and take the appropriate number of tablets. 

Do not take Lonsurf if you are allergic to Lonsurf or to any of its ingredients.

 

Lonsurf Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Lonsurf, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Lonsurf, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Lonsurf or to any of its ingredients
  • have liver problems
  • have kidney problems
  • have or ever had anemia (low red blood cells, neutropenia (low neutrophils) and thrombocytopenia (low platelets) 
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Lonsurf and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

Lonsurf can cause fetal harm when administered to a pregnant woman. Females of reproductive potential are recommended to use effective contraception during treatment with Lonsurf. 

Males with female partners of reproductive potential should use condoms during treatment with Lonsurf and for at least 3 months after the final dose.

Lonsurf and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known whether Lonsurf or its metabolites are present in human milk. There are no data to assess the effects of Lonsurf or its metabolites on the breastfed infant or the effects on milk production. Because of the potential for serious adverse reactions in breastfeeding infants, women should not breastfeed during treatment with Lonsurf and for one day following the final dose.

Lonsurf Usage

Take Lonsurf exactly as prescribed.

It is available in tablet form and is typically taken twice a day, within 1 hour of morning and evening meals.  

Anyone else who handles this medication should wear gloves.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Lonsurf at the same time.

Lonsurf Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your kidney function
  • your age

The recommended dose/dose range of Lonsurf (trifluridine and tipiracil) for the treatment of  is 35 mg/m2/dose orally twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle. 

Lonsurf Overdose

If you take too much Lonsurf, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Lonsurf at 20°C to 25°C (68°F to 77°F).
  • Lonsurf is a cytotoxic drug. Follow applicable special handling and disposal procedures.
  • Keep this and all medicines out of the reach of children.
  • If stored outside of original bottle, discard, following disposal procedures, after 30 days.