Zofran ODT prevents nausea and vomiting by blocking the body's production of serotonin. Zofran ODT can cause headaches, tiredness, and constipation.
Zofran ODT Overview
Zofran ODT is a prescription medication used to prevent nausea and vomiting caused by chemotherapy or surgery. Zofran ODT belongs to a group of drugs called serotonin 5-HT3 antagonists, which block serotonin, a natural chemical in the body, from causing nausea and vomiting.
This medication comes in an orally disintegrating tablet. Place Zofran ODT Tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.
The first oral dose of Zofran ODT is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.
Common side effects include headache, tiredness, and constipation. Zofran ODT can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.
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Zofran ODT Cautionary Labels
Uses of Zofran ODT
Zofran ODT is a prescription medication used for the:
- prevention of nausea and vomiting associated with chemotherapy
- prevention of nausea and vomiting caused by radiation therapy
- prevention of nausea and vomiting caused by surgery
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Zofran ODT Drug Class
Zofran ODT is part of the drug class:
Side Effects of Zofran ODT
Zofran ODT can cause serious side effects. See "Drug Precautions" section.
Common side effects include:
This is not a complete list of Zofran ODT side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Zofran ODT Interactions
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
- apomorphine (Apokyn)
- medications for irregular heart beat
- carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
- phenytoin (Dilantin, Phenytek)
- rifampicin (Rifadin)
- tramadol (Rybix, Rybix ODT, Ultram, Ultram ER)
This is not a complete list of Zofran ODT drug interactions. Ask your doctor or pharmacist for more information.
Zofran ODT Precautions
Serious side effects have been reported with Zofran ODT including:
- hypotension. Zofran ODT and apomorphine (Apokyn) should not be taken at the same time as there is a risk of dangerously low blood pressure and loss of consciousness.
- severe allergic reactions. Hypersensitivity (allergic) reactions have been reported in patients who are allergic to other selective 5-HT3 receptor antagonists.
- changes in heart rhythm. ECG changes including QT interval prolongation has been seen in patients receiving Zofran ODT.
- masking symptoms of intestinal blockage. Using Zofran ODT after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus).
Do not take Zofran ODT if you:
- are allergic to Zofran ODT or any ingredient in it
- are taking apomorphine (Apokyn)
- have long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death)
Zofran ODT can cause drowsiness. Do not drive or operate heavy machinery until you know how Zofran ODT affects you.
Zofran ODT Food Interactions
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Zofran ODT, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking Zofran ODT, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- or anyone in your family has or has ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death)
- have heart disease
- have liver disease
- have an electrolyte imbalance
- have phenylketonuria (PKU). PKU is an inherited condition in which a special diet must be followed to prevent mental retardation. The orally disintegrating tablets (Zofran ODT) contain aspartame that forms phenylalanine.
- are pregnant or breastfeeding
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Zofran ODT and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Zofran ODT falls into category B. There are no good studies that have been done in humans with Zofran ODT. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.
Zofran ODT and Lactation
It is not known if Zofran ODT crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Zofran ODT.
Zofran ODT Usage
- The first oral dose of Zofran ODT is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.
- The orally disintegrating tablets (Zofran ODT) can be taken without water (they dissolve in your mouth).
- For Zofran orally disintegrating tablets (ODTs), you should keep each tablet in its original blister pack until you need it. Do not try to push the tablet through the foil (the tablet is delicate and would be crushed). Instead, gently peel the foil away and remove the tablet.
- IMMEDIATELY place the Zofran ODT Tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.
- If you miss a dose of Zofran ODT, take your next dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of Zofran ODT.
Zofran ODT Dosage
Take Zofran ODT exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The recommended Zofran ODT dose for preventing nausea and vomiting after surgery is 16 mg taken one hour before anesthesia is administered.
High-risk (for nausea and vomiting) chemotherapy: The dose of Zofran ODT for high-risk chemotherapy is 24 mg 30 minutes before chemotherapy.
Medium-risk (for nausea and vomiting) chemotherapy: The dose of Zofran ODT for medium-risk chemotherapy is 8 mg twice daily.
- The first dose should be taken 30 minutes before chemotherapy.
- The second dose should be taken eight hours after the first dose.
- After that, Zofran ODT should be taken twice a day (about every 12 hours) until one to two days after chemotherapy.
The recommended oral dosage of Zofran ODT is one 8 mg given 3 times a day.
Total body irradiation: The dose of Zofran ODT for total body irradiation is 8 mg taken one to two hours before radiotherapy each day of radiation treatment.
Single high-dose fraction radiotherapy to the abdomen: The recommended dose is 8 mg taken one to two hours before radiotherapy followed by 8 mg every eight hours until one to two days after radiation.
Daily fractionated radiotherapy to the abdomen: The recommended dose is 8 mg taken each day one to two hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Dose in Patients with Liver Disease
The dose of Zofran ODT is decreased for people who have poor liver function (hepatic function). People with severely impaired liver function should not take more than 8 mg Zofran ODT total each day.
Zofran ODT Overdose
If you take too much Zofran, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
Keep this and all medications out of the reach of children.