Evkeeza

Evkeeva is a prescription medication used to treat people older than 12 years of age with homozygous familial hypercholesterolemia (HoFH). Evkeeza belongs to a group of drugs called angiopoietin-like 3 (ANGPTL3) inhibitors.

Common side effects include symptoms of the common cold or flu, dizziness, and nausea.

Evkeeza is an injectable prescription medicine used along with other low-density lipoprotein (LDL) lowering medicines in people older than 12 years of age with a type of high cholesterol called homozygous familial hypercholesterolemia (HoFH).
It is not known if Evkeeza is safe and effective in people with other causes of high cholesterol.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

The most common side effects of Evkeeza include:

• symptoms of the common cold
• flu like symptoms
• dizziness
• pain in legs or arms
• nausea
• decreased energy

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of Evkeeza. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Evkeeza can cause serious side effects, including:

• Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Tell your healthcare provider right away if you get any of the following symptoms:
  • swelling – mainly of the lips, tongue or throat which makes it difficult to swallow or breathe
  • breathing problems or wheezing
  • feeling dizzy or fainting
  • rash, hives
  • itching

Do not use Evkeeza if you are allergic to evinacumab-dgnb or to any of the ingredients in Evkeeza. See the end of this leaflet for a complete list of ingredients in Evkeeza.

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Evkeeza, there are no specific foods that you must exclude from your diet when receiving this medication.

Before receiving Evkeeza, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant. Evkeeza may harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if Evkeeza passes into your breast milk. 

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Before starting this medication, tell your doctor if you are pregnant or plan to become pregnant. Evkeeza may harm your unborn baby.

Tell your healthcare provider if you become pregnant while using Evkeeza. 

People who are able to become pregnant:

• Your healthcare provider may do a pregnancy test before you start treatment with Evkeeza
• You should use an effective method of birth control during treatment and for at least 5 months after the last dose of Evkeeza. Talk with your healthcare provider about birth control methods that you can use during this time.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Evkeeza passes into your breast milk. You and your healthcare provider should decide if you will receive Evkeeza or breastfeed.

• Your healthcare provider will give you Evkeeza into your veins through an intravenous (IV) line over 60 minutes.
• Evkeeza should be given every month (4 weeks).
• If you miss any infusion appointments, call your healthcare provider as soon as possible to reschedule.