Motegrity

Motegrity treats a type of constipation called chronic idiopathic constipation. It is important you take it every day as prescribed, not just on days when you are experiencing symptoms.

Motegrity Overview

Reviewed: January 13, 2019
Updated: 

Motegrity is a prescription medication used to treat adults with chronic idiopathic constipation (CIC).

Motegrity belongs to a group of drugs called selective serotonin type 4 receptor agonists. It helps to relieve constipation by targeting a specific receptor in the colon colon called the 5-HT4 receptor. Receptors are molecules that help cells communicate and bring about responses, in this case --colon muscle movements.

Motegrity comes in tablet form and is taken once daily, with or without food.

Common side effects include headache, abdominal pain, nausea, abdominal distension (expansion), dizziness, vomiting, flatulence (gas), and fatigue.

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Motegrity Cautionary Labels

precautionsprecautions

Uses of Motegrity

Motegrity is a prescription medication used to treat chronic idiopathic constipation (CIC) in adults. CIC is constipation that lasts long-term and has no identifable cause.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Prucalopride

For more information on this medication choose from the list of selections below.

Motegrity Drug Class

Motegrity is part of the drug class:

Side Effects of Motegrity

Serious side effects have been reported with Motegrity. See the “Motegrity Precautions” section.

Common side effects of Motegrity include the following:

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Abdominal distention (expansion)
  • Dizziness
  • Vomiting
  • Flatulence (gas)
  • Fatigue

This is not a complete list of Motegrity side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have any side effects that bother you or that do not go away.

You may report side effects to the FDA at 1-800-FDA-1088.

Motegrity Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • medications that block the p-glycoprotein transporter such as
    • amiodarone (Cordarone, Pacerone)
    • azithromycin (Zithromax, Zmax)
    • captopril (Capoten)
    • carvedilol (Coreg)
    • clarithromycin (Biaxin)
    • conivaptan (Vaprisol)
    • cyclosporine (Neoral, Sandimmune, Gengraf)
    • diltiazem (Cardizem), dronedarone (Multaq)
    • erythromycin (EES, Ery-Tab)
    • felodipine (Plendil)
    • itraconazole (Sporanox, Onmel)
    • ketoconazole (Nizoral)
    • lopinavir and ritonavir (Kaletra)
    • quinidine (Cardioquine, Quinact, Duraquin)
    • ranolazine (Ranexa)
    • verapamil (Calan, Isoptin, Covera, Verelan)

This is not a complete list of Motegrity drug interactions. Ask your doctor or pharmacist for more information.

Motegrity Precautions

Serious side effects have been reported with Motegrity including

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or have tried to hurt yourself.

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease or ulcerative colitis.

Motegrity Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Motegrity, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Motegrity, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems.
  • have kidney problems. Your healthcare provider may give you a lower dose.
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby if you take Motegrity.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Motegrity and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

In animal studies, pregnant animals were given this medication and no babies were observed to be born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Motegrity and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Motegrity has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Motegrity, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Motegrity Usage

Take Motegrity exactly as prescribed.

Motegrity comes in tablet form and is taken once daily, with or without food.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at the same time.

Motegrity Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
 
The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The recommended dose/dose range of Motegrity (prucalopride) for the treatment of chronic idiopathic constipation is 2 mg every day. It may be reduced to 1 mg every day for patients with impaired kdiney function. 

Motegrity Overdose

If you take too much Motegrity, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Motegrity at room temperature between 68°F to 77°F (20°C to 25°C).
  • Store Motegrity in the original container to protect from moisture. 
  • Keep Motegrity and all medicines out of the reach of children.